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Malignant neoplasm of oesophagus

Endpoint Browser PheWeb

C3_OESOPHAGUS_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C15
  • Cause of death: ICD-9 — 150
  • Cause of death: ICD-8 — 150
  • Cancer registry: Topography ICD-O-3 — C15
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9326 2999 6072
Only index persons 4371 1297 3074
Unadjusted period prevalence (%)
Whole population 0.15 0.09 0.17
Only index persons 0.10 0.05 0.12
Median age at first event (years)
Whole population 68.92 72.68 67.19
Only index persons 70.02 74.15 68.28

-FinnGen-

Key figures

All Female Male
Number of individuals 763 167 596
Unadjusted period prevalence (%) 0.25 0.07 0.30
Median age at first event (years) 69.35 70.10 69.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_OESOPHAGUS_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_OESOPHAGUS_EXALLC 14.524 [9.21, 22.92] < 0.001
Birth year 0.995 [0.99, 1.0] 0.215

During the follow-up period (1.1.1998 — 31.12.2019), 1201 out of 1451 females with C3_OESOPHAGUS_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_OESOPHAGUS_EXALLC 17.331 [11.97, 25.09] < 0.001
Birth year 0.988 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 2836 out of 3396 males with C3_OESOPHAGUS_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_OESOPHAGUS_EXALLC.

N-year risk Females Males
1 1.406% 4.197%
5 8.229% 17.818%
10 20.192% 38.185%
15 34.075% 61.496%
20 52.322% 81.496%

Relationships between endpoints

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Index endpoint: C3_OESOPHAGUS_EXALLC – Malignant neoplasm of oesophagus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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