No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Control conditions
not HLP_C3_NSCLC_SQUAM
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Non-small cell lung cancer, squamous
based on the number of shared cases.
Similar with more cases:
- Non-small cell lung cancer, squamous
- Non-small cell lung cancer, squamous
- Non-small cell lung cancer
- Non-small cell lung cancer
- Malignant neoplasm of bronchus and lung
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 21794 | 2866 | 17935 |
| Only index persons | 6675 | 1588 | 5087 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.47 | 0.08 | 0.50 |
| Only index persons | 0.16 | 0.06 | 0.19 |
| Median age at first event (years) | |||
| Whole population | 67.38 | 69.07 | 67.21 |
| Only index persons | 70.90 | 70.57 | 71.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1787 | 242 | 1545 |
| Unadjusted period prevalence (%) | 0.68 | 0.10 | 0.78 |
| Median age at first event (years) | 71.97 | 70.11 | 72.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_NSCLC_SQUAM_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_NSCLC_SQUAM_EXALLC | 17.681 [13.05, 23.95] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.102 |
During the follow-up period (1.1.1998 — 31.12.2019), 1386 out of 1760 females with C3_NSCLC_SQUAM_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_NSCLC_SQUAM_EXALLC | 12.793 [10.11, 16.18] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 5699 out of 6634 males with C3_NSCLC_SQUAM_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_NSCLC_SQUAM_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.234% | 1.838% |
| 5 | 9.045% | 11.975% |
| 10 | 20.7% | 25.399% |
| 15 | 36.306% | 42.545% |
| 20 | 55.729% | 61.59% |
Relationships between endpoints
↥Index endpoint: C3_NSCLC_SQUAM_EXALLC – Non-small cell lung cancer, squamous
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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