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Malignant neoplasm of nasal cavity and sinuses

Endpoint Browser PheWeb

C3_NASAL_CAVITY_SINUSES_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C30, C31
  • Cause of death: ICD-9 — 160
  • Cause of death: ICD-8 — 160
  • Cancer registry: Topography ICD-O-3 — C3[01]
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF9

Similar endpoints

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List of similar endpoints to Malignant neoplasm of nasal cavity and sinuses based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1946 787 1122
Only index persons 1040 438 602
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 65.34 68.06 63.59
Only index persons 66.82 68.80 65.38

-FinnGen-

Key figures

All Female Male
Number of individuals 193 74 119
Unadjusted period prevalence (%) 0.05 0.03 0.06
Median age at first event (years) 64.80 63.97 65.32

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint C3_NASAL_CAVITY_SINUSES_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_NASAL_CAVITY_SINUSES_EXALLC 4.187 [3.03, 5.78] < 0.001
Birth year 0.997 [0.99, 1.0] 0.42

During the follow-up period (1.1.1998 — 31.12.2019), 269 out of 462 females with C3_NASAL_CAVITY_SINUSES_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_NASAL_CAVITY_SINUSES_EXALLC 3.958 [2.84, 5.52] < 0.001
Birth year 0.989 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 351 out of 639 males with C3_NASAL_CAVITY_SINUSES_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_NASAL_CAVITY_SINUSES_EXALLC.

N-year risk Females Males
1 0.383% 0.728%
5 2.43% 4.554%
10 6.114% 12.387%
15 11.702% 21.89%
20 20.324% 34.745%

Relationships between endpoints

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Index endpoint: C3_NASAL_CAVITY_SINUSES_EXALLC – Malignant neoplasm of nasal cavity and sinuses

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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