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Mesothelioma

Endpoint Browser PheWeb

C3_MESOTHELIOMA_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C45
  • Hospital discharge: ICD-9 — 158|163
  • Hospital discharge: ICD-8 — 158|163
  • Cause of death: ICD-10 — C45
  • Cause of death: ICD-9 — 158|163
  • Cause of death: ICD-8 — 158|163
  • Cancer registry: Topography ICD-O-3 — ANY
  • Cancer registry: Morphology ICD-O-3 — 905[0-3]
  • Cancer registry: Behaviour codes — 3

3 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF8
Parent code in ICD-10 C45-C49
Name in latin Mesothelioma

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5562 1900 3473
Only index persons 2054 696 1358
Unadjusted period prevalence (%)
Whole population 0.09 0.05 0.10
Only index persons 0.04 0.03 0.05
Median age at first event (years)
Whole population 67.16 67.14 67.35
Only index persons 70.63 69.35 71.29

-FinnGen-

Key figures

All Female Male
Number of individuals 390 92 298
Unadjusted period prevalence (%) 0.12 0.04 0.15
Median age at first event (years) 70.20 63.72 72.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_MESOTHELIOMA_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_MESOTHELIOMA_EXALLC 5.972 [4.26, 8.37] < 0.001
Birth year 0.998 [0.99, 1.01] 0.608

During the follow-up period (1.1.1998 — 31.12.2019), 551 out of 724 females with C3_MESOTHELIOMA_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_MESOTHELIOMA_EXALLC 12.814 [8.61, 19.06] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 1391 out of 1598 males with C3_MESOTHELIOMA_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_MESOTHELIOMA_EXALLC.

N-year risk Females Males
1 0.559% 2.316%
5 3.196% 13.386%
10 8.392% 29.649%
15 16.269% 51.616%
20 27.686% 72.816%

Relationships between endpoints

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Index endpoint: C3_MESOTHELIOMA_EXALLC – Mesothelioma

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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