No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF9
Similar endpoints
↥List of similar endpoints to
Neuroendocrine tumor and carcinoma of lung
based on the number of shared cases.
Similar with more cases:
- Neuroendocrine tumor and carcinoma of lung
- Malignant neoplasm of bronchus and lung
- Malignant neoplasm of bronchus and lung
- Malignant neoplasm of respiratory system and intrathoracic organs
- Malignant neoplasm of respiratory system and intrathoracic organs
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1382 | 774 | 592 |
| Only index persons | 1123 | 664 | 459 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 64.17 | 64.54 | 63.77 |
| Only index persons | 64.15 | 64.29 | 63.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 229 | 145 | 84 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | 65.03 | 64.31 | 66.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint C3_LUNG_NEUROENDO_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_LUNG_NEUROENDO_EXALLC | 4.348 [3.28, 5.77] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.059 |
During the follow-up period (1.1.1998 — 31.12.2019), 181 out of 515 females with C3_LUNG_NEUROENDO_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_LUNG_NEUROENDO_EXALLC | 5.316 [3.66, 7.71] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 207 out of 386 males with C3_LUNG_NEUROENDO_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_LUNG_NEUROENDO_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.379% | 1.042% |
| 5 | 1.976% | 5.785% |
| 10 | 5.368% | 13.812% |
| 15 | 10.185% | 24.171% |
| 20 | 17.004% | 38.074% |
Relationships between endpoints
↥Index endpoint: C3_LUNG_NEUROENDO_EXALLC – Neuroendocrine tumor and carcinoma of lung
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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