No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Leiomyosarcoma
based on the number of shared cases.
Similar with more cases:
- Leiomyosarcoma
- Malignant neoplasm
- Malignant neoplasm
- Any event in cancer register
- Malignant neoplasm, wide definition for exclusion
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2431 | 1595 | 793 |
| Only index persons | 1350 | 891 | 459 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 60.12 | 57.94 | 64.38 |
| Only index persons | 60.59 | 57.46 | 66.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 210 | 141 | 69 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | 59.25 | 56.49 | 64.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint C3_LEIOMYOSARCOMA_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_LEIOMYOSARCOMA_EXALLC | 6.422 [4.78, 8.63] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.176 |
During the follow-up period (1.1.1998 — 31.12.2019), 443 out of 785 females with C3_LEIOMYOSARCOMA_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_LEIOMYOSARCOMA_EXALLC | 2.27 [1.65, 3.13] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 198 out of 425 males with C3_LEIOMYOSARCOMA_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_LEIOMYOSARCOMA_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.602% | 0.387% |
| 5 | 3.664% | 2.65% |
| 10 | 8.882% | 6.522% |
| 15 | 17.035% | 11.987% |
| 20 | 27.888% | 19.098% |
Relationships between endpoints
↥Index endpoint: C3_LEIOMYOSARCOMA_EXALLC – Leiomyosarcoma
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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