No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Fibrosarcoma
based on the number of shared cases.
Similar with more cases:
- Fibrosarcoma
- Malignant neoplasm
- Malignant neoplasm
- Any event in cancer register
- Malignant neoplasm, wide definition for exclusion
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2775 | 1326 | 1389 |
| Only index persons | 1685 | 856 | 829 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 54.62 | 54.26 | 54.68 |
| Only index persons | 49.38 | 49.77 | 48.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 216 | 103 | 113 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | 51.59 | 51.57 | 51.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint C3_FIBROSARCOMA_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_FIBROSARCOMA_EXALLC | 2.425 [1.88, 3.13] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.679 |
During the follow-up period (1.1.1998 — 31.12.2019), 222 out of 585 females with C3_FIBROSARCOMA_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_FIBROSARCOMA_EXALLC | 2.236 [1.7, 2.94] | < 0.001 |
| Birth year | 0.984 [0.97, 1.0] | 0.033 |
During the follow-up period (1.1.1998 — 31.12.2019), 284 out of 647 males with C3_FIBROSARCOMA_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_FIBROSARCOMA_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | 0.377% |
| 5 | 1.448% | 2.204% |
| 10 | 3.899% | 5.819% |
| 15 | 7.689% | 11.13% |
| 20 | 12.854% | 18.463% |
Relationships between endpoints
↥Index endpoint: C3_FIBROSARCOMA_EXALLC – Fibrosarcoma
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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