Malignant neoplasm of eye and adnexa

C3_EYE_ADNEXA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C69
  • Cause of death: ICD-9 190
  • Cause of death: ICD-8 190
  • Cancer registry: Topography ICD-O-3 C69
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF9

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2814 1357 1408
Only index persons 1753 884 869
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 59.78 59.91 59.58
Only index persons 59.31 60.12 58.49

-FinnGen-

Key figures

All Female Male
Number of individuals 256 120 136
Unadjusted period prevalence (%) 0.06 0.05 0.07
Median age at first event (years) 60.19 58.68 61.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint C3_EYE_ADNEXA_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_EYE_ADNEXA_EXALLC 2.649 [2.12, 3.3] < 0.001
Birth year 0.992 [0.98, 1.0] 0.082

During the follow-up period (1.1.1998 — 31.12.2019), 279 out of 682 females with C3_EYE_ADNEXA_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_EYE_ADNEXA_EXALLC 2.222 [1.72, 2.86] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 330 out of 728 males with C3_EYE_ADNEXA_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_EYE_ADNEXA_EXALLC.

N-year risk Females Males
1 0.17% 0.402%
5 1.452% 1.995%
10 3.479% 5.253%
15 6.5% 9.999%
20 11.715% 16.957%

Relationships between endpoints

Index endpoint: C3_EYE_ADNEXA_EXALLC – Malignant neoplasm of eye and adnexa

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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