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Diffuse large B-cell lymphoma

Endpoint Browser PheWeb

C3_DLBCL_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

  • HLP_C3_DLBCL
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3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C83.3
  • Cause of death: ICD-9 — 2000B
  • Cancer registry: Topography ICD-O-3 — ANY
  • Cancer registry: Morphology ICD-O-3 — 9680
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not HLP_C3_DLBCL

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9142 4536 4558
Only index persons 8141 3936 4205
Unadjusted period prevalence (%)
Whole population 0.13 0.13 0.13
Only index persons 0.15 0.14 0.16
Median age at first event (years)
Whole population 70.38 71.49 69.28
Only index persons 70.10 71.16 69.12

-FinnGen-

Key figures

All Female Male
Number of individuals 1373 596 777
Unadjusted period prevalence (%) 0.32 0.23 0.39
Median age at first event (years) 67.92 66.64 68.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_DLBCL_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_DLBCL_EXALLC 4.307 [3.61, 5.14] < 0.001
Birth year 0.992 [0.98, 1.0] 0.059

During the follow-up period (1.1.1998 — 31.12.2019), 1727 out of 3611 females with C3_DLBCL_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_DLBCL_EXALLC 3.739 [3.09, 4.52] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 1756 out of 3747 males with C3_DLBCL_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_DLBCL_EXALLC.

N-year risk Females Males
1 0.413% 0.794%
5 2.445% 4.711%
10 5.934% 10.92%
15 10.831% 19.986%
20 18.299% 32.021%

Relationships between endpoints

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Index endpoint: C3_DLBCL_EXALLC – Diffuse large B-cell lymphoma

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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