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Malignant neoplasm of breast, HER-positive

Endpoint Browser PheWeb

C3_BREAST_ERPLUS_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

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2. Check conditions

  • RX_ERPLUS
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3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C50
  • Cause of death: ICD-9 — 174
  • Cause of death: ICD-8 — 174
  • Cancer registry: Topography ICD-O-3 — C50
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — [23]

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not RX_ERPLUS

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 70180 70180 -
Only index persons 63308 63308 -
Unadjusted period prevalence (%)
Whole population 2.01 2.01 -
Only index persons 2.33 2.33 -
Median age at first event (years)
Whole population - 61.49 -
Only index persons - 61.50 -

-FinnGen-

Key figures

All Female Male
Number of individuals 12081 12081 -
Unadjusted period prevalence (%) 4.74 4.74 -
Median age at first event (years) 59.90 59.90 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_BREAST_ERPLUS_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_BREAST_ERPLUS_EXALLC 1.707 [1.56, 1.87] < 0.001
Birth year 0.994 [0.99, 1.0] 0.112

During the follow-up period (1.1.1998 — 31.12.2019), 12606 out of 58236 females with C3_BREAST_ERPLUS_EXALLC died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have C3_BREAST_ERPLUS_EXALLC.

N-year risk Females Males
1 0.132% No data
5 0.831% No data
10 2.098% No data
15 4.195% No data
20 7.418% No data

Relationships between endpoints

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Index endpoint: C3_BREAST_ERPLUS_EXALLC – Malignant neoplasm of breast, HER-positive

GWS hits: 45

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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