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Malignant neoplasm of bladder

Endpoint Browser PheWeb

C3_BLADDER_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C67
  • Cause of death: ICD-9 — 188
  • Cause of death: ICD-8 — 188
  • Cancer registry: Topography ICD-O-3 — C67
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 26494 5491 20344
Only index persons 15280 3598 11682
Unadjusted period prevalence (%)
Whole population 0.49 0.16 0.57
Only index persons 0.37 0.13 0.45
Median age at first event (years)
Whole population 71.39 73.24 70.91
Only index persons 71.24 72.69 70.79

-FinnGen-

Key figures

All Female Male
Number of individuals 2574 405 2169
Unadjusted period prevalence (%) 0.94 0.16 1.09
Median age at first event (years) 70.66 67.87 71.18

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_BLADDER_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_BLADDER_EXALLC 2.136 [1.88, 2.43] < 0.001
Birth year 0.992 [0.98, 1.0] 0.066

During the follow-up period (1.1.1998 — 31.12.2019), 1925 out of 3296 females with C3_BLADDER_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_BLADDER_EXALLC 2.016 [1.82, 2.23] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 6835 out of 11512 males with C3_BLADDER_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_BLADDER_EXALLC.

N-year risk Females Males
1 0.211% 0.366%
5 1.04% 2.237%
10 2.616% 5.196%
15 5.443% 10.108%
20 9.629% 16.384%

Relationships between endpoints

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Index endpoint: C3_BLADDER_EXALLC – Malignant neoplasm of bladder

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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