Basal cell carcinoma, including avohilmo

C3_BASAL_CELL_CARCINOMA_INCLAVO_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

1 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF9

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 129419 68971 59907
Only index persons 120165 64764 55401
Unadjusted period prevalence (%)
Whole population 1.83 1.98 1.67
Only index persons 2.26 2.38 2.11
Median age at first event (years)
Whole population 74.14 74.60 73.60
Only index persons 73.78 74.19 73.31

-FinnGen-

Key figures

All Female Male
Number of individuals 23936 11555 12381
Unadjusted period prevalence (%) 5.41 4.54 6.22
Median age at first event (years) 68.40 67.00 69.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint C3_BASAL_CELL_CARCINOMA_INCLAVO_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_BASAL_CELL_CARCINOMA_INCLAVO_EXALLC 0.977 [0.89, 1.07] 0.631
Birth year 0.995 [0.99, 1.0] 0.189

During the follow-up period (1.1.1998 — 31.12.2019), 15622 out of 56089 females with C3_BASAL_CELL_CARCINOMA_INCLAVO_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_BASAL_CELL_CARCINOMA_INCLAVO_EXALLC 0.957 [0.86, 1.06] 0.412
Birth year 0.987 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 15173 out of 48341 males with C3_BASAL_CELL_CARCINOMA_INCLAVO_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_BASAL_CELL_CARCINOMA_INCLAVO_EXALLC.

N-year risk Females Males
1 0.073% 0.156%
5 0.473% 0.995%
10 1.282% 2.585%
15 2.678% 5.036%
20 4.546% 8.682%

Relationships between endpoints

Index endpoint: C3_BASAL_CELL_CARCINOMA_INCLAVO_EXALLC – Basal cell carcinoma, including avohilmo

GWS hits: 80

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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