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Malignant neoplasm of anus and anal canal

Endpoint Browser PheWeb

C3_ANUS_ANALCANAL_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C21
  • Cause of death: ICD-9 — 154[2-3]
  • Cause of death: ICD-8 — 1542
  • Cancer registry: Topography ICD-O-3 — C21
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1355 788 545
Only index persons 906 556 350
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 66.79 66.61 67.23
Only index persons 65.20 64.72 65.96

-FinnGen-

Key figures

All Female Male
Number of individuals 134 85 49
Unadjusted period prevalence (%) 0.03 0.03 0.02
Median age at first event (years) 65.66 63.53 69.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint C3_ANUS_ANALCANAL_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_ANUS_ANALCANAL_EXALLC 3.937 [2.87, 5.4] < 0.001
Birth year 0.998 [0.99, 1.01] 0.666

During the follow-up period (1.1.1998 — 31.12.2019), 249 out of 532 females with C3_ANUS_ANALCANAL_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_ANUS_ANALCANAL_EXALLC 4.43 [2.8, 7.01] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 326 males with C3_ANUS_ANALCANAL_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_ANUS_ANALCANAL_EXALLC.

N-year risk Females Males
1 0.352% 0.776%
5 2.209% 4.459%
10 5.703% 11.023%
15 11.237% 20.414%
20 18.915% 33.0%

Relationships between endpoints

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Index endpoint: C3_ANUS_ANALCANAL_EXALLC – Malignant neoplasm of anus and anal canal

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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