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Malignant neoplasm of adrenal gland

Endpoint Browser PheWeb

C3_ADRENAL_GLAND_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C74
  • Cause of death: ICD-9 — 1940
  • Cause of death: ICD-8 — 1940
  • Cancer registry: Topography ICD-O-3 — C74
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1240 590 623
Only index persons 583 315 268
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 54.74 52.35 56.69
Only index persons 55.35 54.60 56.22

-FinnGen-

Key figures

All Female Male
Number of individuals 120 56 64
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 55.18 47.05 62.30

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint C3_ADRENAL_GLAND_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_ADRENAL_GLAND_EXALLC 8.121 [4.39, 15.01] < 0.001
Birth year 1.0 [0.99, 1.01] 0.971

During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 291 females with C3_ADRENAL_GLAND_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_ADRENAL_GLAND_EXALLC 7.598 [3.71, 15.58] < 0.001
Birth year 0.988 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 118 out of 254 males with C3_ADRENAL_GLAND_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_ADRENAL_GLAND_EXALLC.

N-year risk Females Males
1 0.746% 1.536%
5 5.424% 9.104%
10 12.456% 21.004%
15 23.53% 36.42%
20 38.69% 56.065%

Relationships between endpoints

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Index endpoint: C3_ADRENAL_GLAND_EXALLC – Malignant neoplasm of adrenal gland

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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