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Other specified/unspecified bacterial intestinal infections

DOID EFO Endpoint Browser PheWeb

BACT_INTEST_INFECTION_NOS

dysentery: Acute inflammation of the intestine associated with infectious diarrhea of various etiologies, generally acquired by eating contaminated food containing toxins, biological derived from bacteria or other microorganisms. Dysentery is characterized initially by watery feces then by bloody mucoid stools. It is often associated with abdominal pain; fever; and dehydration.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A04.8, A04.9
  • Hospital discharge: ICD-9 — 0085X
  • Hospital discharge: ICD-8 — 008[2-3]
  • Cause of death: ICD-10 — A04.8, A04.9
  • Cause of death: ICD-9 — 0085X
  • Cause of death: ICD-8 — 008[2-3]

2 out of 7 registries used, show all original rules.

2278

4. Check minimum number of events

None

2278

5. Include endpoints

None

2278

6. Filter based on genotype QC (FinnGen only)

2130

Control definitions (FinnGen only)

Control exclude IBD_BACT_INTEST_INFECTIONS

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19610 10540 8850
Only index persons 17779 9739 8040
Unadjusted period prevalence (%)
Whole population 0.28 0.30 0.25
Only index persons 0.33 0.36 0.31
Median age at first event (years)
Whole population 56.05 57.55 54.55
Only index persons 55.03 56.29 53.51

-FinnGen-

Key figures

All Female Male
Number of individuals 2130 1222 908
Unadjusted period prevalence (%) 0.47 0.48 0.46
Median age at first event (years) 57.43 55.48 60.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint BACT_INTEST_INFECTION_NOS and mortality.

Females

Parameter HR [95% CI] p-value
BACT_INTEST_INFECTION_NOS 1.44 [1.3, 1.59] < 0.001
Birth year 0.996 [0.99, 1.0] 0.395

During the follow-up period (1.1.1998 — 31.12.2019), 1975 out of 8826 females with BACT_INTEST_INFECTION_NOS died.

Males

Parameter HR [95% CI] p-value
BACT_INTEST_INFECTION_NOS 1.523 [1.36, 1.7] < 0.001
Birth year 0.988 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 1788 out of 7300 males with BACT_INTEST_INFECTION_NOS died.

Mortality risk

Mortality risk for people of age

years, who have BACT_INTEST_INFECTION_NOS.

N-year risk Females Males
1 0.152% 0.277%
5 0.866% 1.927%
10 2.158% 4.459%
15 4.255% 8.802%
20 7.375% 14.502%

Relationships between endpoints

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Index endpoint: BACT_INTEST_INFECTION_NOS – Other specified/unspecified bacterial intestinal infections

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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