Yersinia pestis infectious disease: Plague is a severe bacterial infection caused by the gram-negative bacterium Yersinia pestis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
594 |
4. Check minimum number of eventsNone |
594 |
5. Include endpoints |
594 |
6. Filter based on genotype QC (FinnGen only) |
570 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Certain zoonotic bacterial diseases
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6494 | 3019 | 3435 |
| Only index persons | 5630 | 2662 | 2968 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.09 | 0.10 |
| Only index persons | 0.11 | 0.10 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 47.98 | 48.65 | 47.21 |
| Only index persons | 45.99 | 46.97 | 45.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 570 | 289 | 281 |
| Unadjusted period prevalence (%) | 0.13 | 0.11 | 0.14 |
| Median age at first event (years) | 50.30 | 47.44 | 53.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint AB1_ZOONOTIC_BACTERIAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_ZOONOTIC_BACTERIAL | 1.32 [1.11, 1.57] | 0.002 |
| Birth year | 0.998 [0.99, 1.01] | 0.644 |
During the follow-up period (1.1.1998 — 31.12.2019), 303 out of 1976 females with AB1_ZOONOTIC_BACTERIAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_ZOONOTIC_BACTERIAL | 1.111 [0.96, 1.29] | 0.16 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 369 out of 2439 males with AB1_ZOONOTIC_BACTERIAL died.
Mortality risk
Mortality risk for people of age
years, who have AB1_ZOONOTIC_BACTERIAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.128% | 0.284% |
| 5 | 0.806% | 1.415% |
| 10 | 2.18% | 3.598% |
| 15 | 4.413% | 6.727% |
| 20 | 7.549% | 11.22% |
Relationships between endpoints
↥Index endpoint: AB1_ZOONOTIC_BACTERIAL – Certain zoonotic bacterial diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data