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Tularaemia

Endpoint Browser PheWeb

AB1_TULARAEMIA

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A21
  • Hospital discharge: ICD-9 — 02[1]
  • Hospital discharge: ICD-8 — 02[1]
  • Cause of death: ICD-10 — A21
  • Cause of death: ICD-9 — 02[1]
  • Cause of death: ICD-8 — 02[1]

2 out of 7 registries used, show all original rules.

404

4. Check minimum number of events

None

404

5. Include endpoints

None

404

6. Filter based on genotype QC (FinnGen only)

391

Control definitions (FinnGen only)

Control exclude AB1_ZOONOTIC_BACTERIAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4460 1976 2467
Only index persons 4103 1830 2273
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.07
Only index persons 0.08 0.07 0.09
Median age at first event (years)
Whole population 46.83 48.39 45.50
Only index persons 46.01 47.63 44.71

-FinnGen-

Key figures

All Female Male
Number of individuals 391 190 201
Unadjusted period prevalence (%) 0.09 0.07 0.10
Median age at first event (years) 50.35 48.28 52.30

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint AB1_TULARAEMIA and mortality.

Females

Parameter HR [95% CI] p-value
AB1_TULARAEMIA 0.971 [0.78, 1.21] 0.798
Birth year 0.996 [0.99, 1.0] 0.411

During the follow-up period (1.1.1998 — 31.12.2019), 131 out of 1400 females with AB1_TULARAEMIA died.

Males

Parameter HR [95% CI] p-value
AB1_TULARAEMIA 0.804 [0.68, 0.95] 0.011
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 193 out of 1871 males with AB1_TULARAEMIA died.

Mortality risk

Mortality risk for people of age

years, who have AB1_TULARAEMIA.

N-year risk Females Males
1 0.079% 0.134%
5 0.564% 0.855%
10 1.485% 2.14%
15 2.888% 4.126%
20 4.936% 7.341%

Relationships between endpoints

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Index endpoint: AB1_TULARAEMIA – Tularaemia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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