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Scabies

Endpoint Browser PheWeb

AB1_SCABIES

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B86
  • Hospital discharge: ICD-9 — 1330A
  • Hospital discharge: ICD-8 — 1330
  • Cause of death: ICD-10 — B86
  • Cause of death: ICD-9 — 1330A
  • Cause of death: ICD-8 — 1330

2 out of 7 registries used, show all original rules.

1509

4. Check minimum number of events

None

1509

5. Include endpoints

None

1509

6. Filter based on genotype QC (FinnGen only)

1462

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 18964 6637 12241
Only index persons 16643 5825 10818
Unadjusted period prevalence (%)
Whole population 0.29 0.19 0.34
Only index persons 0.34 0.21 0.41
Median age at first event (years)
Whole population 20.91 21.44 20.50
Only index persons 21.13 22.22 20.54

-FinnGen-

Key figures

All Female Male
Number of individuals 1462 625 837
Unadjusted period prevalence (%) 0.35 0.25 0.42
Median age at first event (years) 24.50 28.77 21.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_SCABIES and mortality.

Females

Parameter HR [95% CI] p-value
AB1_SCABIES 1.897 [1.55, 2.32] < 0.001
Birth year 0.994 [0.99, 1.0] 0.188

During the follow-up period (1.1.1998 — 31.12.2019), 457 out of 3923 females with AB1_SCABIES died.

Males

Parameter HR [95% CI] p-value
AB1_SCABIES 2.234 [1.83, 2.72] < 0.001
Birth year 0.979 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 631 out of 5243 males with AB1_SCABIES died.

Mortality risk

Mortality risk for people of age

years, who have AB1_SCABIES.

N-year risk Females Males
1 0.172% 0.316%
5 1.17% 1.926%
10 2.837% 5.155%
15 5.23% 9.718%
20 9.268% 15.581%

Relationships between endpoints

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Index endpoint: AB1_SCABIES – Scabies

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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