No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
16041 |
4. Check minimum number of eventsNone |
16041 |
5. Include endpointsNone |
16041 |
6. Filter based on genotype QC (FinnGen only) |
15222 |
Control definitions (FinnGen only)
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Z3
Similar endpoints
↥List of similar endpoints to
Procreative management
based on the number of shared cases.
Similar with more cases:
- Persons encountering health services in circumstances related to reproduction
- Factors influencing health status and contact with health services
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 108423 | 54794 | 52100 |
| Only index persons | 101454 | 52320 | 49134 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.52 | 1.57 | 1.46 |
| Only index persons | 1.90 | 1.92 | 1.88 |
| Median age at first event (years) | |||
| Whole population | 33.71 | 34.18 | 33.24 |
| Only index persons | 34.16 | 34.62 | 33.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 15222 | 10298 | 4924 |
| Unadjusted period prevalence (%) | 3.54 | 4.04 | 2.47 |
| Median age at first event (years) | 37.27 | 37.75 | 36.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint Z21_PROCREATIVE_MANAG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Z21_PROCREATIVE_MANAG | 1.835 [1.56, 2.15] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.241 |
During the follow-up period (1.1.1998 — 31.12.2019), 1293 out of 44074 females with Z21_PROCREATIVE_MANAG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Z21_PROCREATIVE_MANAG | 1.062 [0.92, 1.22] | 0.405 |
| Birth year | 0.985 [0.97, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 999 out of 44082 males with Z21_PROCREATIVE_MANAG died.
Mortality risk
Mortality risk for people of age
years, who have Z21_PROCREATIVE_MANAG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.206% | 0.153% |
| 5 | 1.008% | 1.065% |
| 10 | 2.536% | 2.786% |
| 15 | 5.048% | 5.384% |
| 20 | 8.67% | 9.006% |
Relationships between endpoints
↥Index endpoint: Z21_PROCREATIVE_MANAG – Procreative management
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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