Problems related to medical facilities and other health care

Z21_PROBL_RELATED_MEDICAL_FACILITI_OTH_HEALTH_CARE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Z75
  • Cause of death: ICD-10 Z75

2 out of 7 registries used, show all original rules.

2253

4. Check minimum number of events

None

2253

5. Include endpoints

None

2253

6. Filter based on genotype QC (FinnGen only)

2155

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4
Parent code in ICD-10 Z7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 39465 20781 17877
Only index persons 26009 14602 11407
Unadjusted period prevalence (%)
Whole population 0.56 0.60 0.50
Only index persons 0.49 0.54 0.44
Median age at first event (years)
Whole population 78.09 79.68 76.23
Only index persons 76.87 78.62 74.62

-FinnGen-

Key figures

All Female Male
Number of individuals 2155 994 1161
Unadjusted period prevalence (%) 0.49 0.39 0.58
Median age at first event (years) 73.10 71.46 74.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint Z21_PROBL_RELATED_MEDICAL_FACILITI_OTH_HEALTH_CARE and mortality.

Females

Parameter HR [95% CI] p-value
Z21_PROBL_RELATED_MEDICAL_FACILITI_OTH_HEALTH_CARE 2.28 [2.07, 2.52] < 0.001
Birth year 0.997 [0.99, 1.0] 0.429

During the follow-up period (1.1.1998 — 31.12.2019), 13024 out of 18209 females with Z21_PROBL_RELATED_MEDICAL_FACILITI_OTH_HEALTH_CARE died.

Males

Parameter HR [95% CI] p-value
Z21_PROBL_RELATED_MEDICAL_FACILITI_OTH_HEALTH_CARE 2.876 [2.5, 3.31] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 11614 out of 15538 males with Z21_PROBL_RELATED_MEDICAL_FACILITI_OTH_HEALTH_CARE died.

Mortality risk

Mortality risk for people of age

years, who have Z21_PROBL_RELATED_MEDICAL_FACILITI_OTH_HEALTH_CARE.

N-year risk Females Males
1 0.26% 0.641%
5 1.391% 3.286%
10 3.355% 8.02%
15 6.24% 14.528%
20 10.962% 23.933%

Relationships between endpoints

Index endpoint: Z21_PROBL_RELATED_MEDICAL_FACILITI_OTH_HEALTH_CARE – Problems related to medical facilities and other health care

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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