Previous suicide attempt

Z21_PREVIOUS_SUICIDE_ATTEMPT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Z91.5
  • Cause of death: ICD-10 Z91.5

2 out of 7 registries used, show all original rules.

321

4. Check minimum number of events

None

321

5. Include endpoints

None

321

6. Filter based on genotype QC (FinnGen only)

308

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3610 1924 1673
Only index persons 3305 1828 1477
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.05
Only index persons 0.06 0.07 0.06
Median age at first event (years)
Whole population 30.26 24.62 36.62
Only index persons 29.01 23.99 35.22

-FinnGen-

Key figures

All Female Male
Number of individuals 308 201 107
Unadjusted period prevalence (%) 0.07 0.08 0.05
Median age at first event (years) 34.75 30.59 42.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint Z21_PREVIOUS_SUICIDE_ATTEMPT and mortality.

Females

Parameter HR [95% CI] p-value
Z21_PREVIOUS_SUICIDE_ATTEMPT 4.387 [3.26, 5.9] < 0.001
Birth year 0.992 [0.98, 1.0] 0.091

During the follow-up period (1.1.1998 — 31.12.2019), 166 out of 1423 females with Z21_PREVIOUS_SUICIDE_ATTEMPT died.

Males

Parameter HR [95% CI] p-value
Z21_PREVIOUS_SUICIDE_ATTEMPT 4.765 [3.67, 6.19] < 0.001
Birth year 0.995 [0.99, 1.0] 0.261

During the follow-up period (1.1.1998 — 31.12.2019), 309 out of 1255 males with Z21_PREVIOUS_SUICIDE_ATTEMPT died.

Mortality risk

Mortality risk for people of age

years, who have Z21_PREVIOUS_SUICIDE_ATTEMPT.

N-year risk Females Males
1 0.414% 1.089%
5 2.367% 6.996%
10 5.881% 16.466%
15 11.087% 29.163%
20 18.56% 45.816%

Relationships between endpoints

Index endpoint: Z21_PREVIOUS_SUICIDE_ATTEMPT – Previous suicide attempt

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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