Asymptomatic human immunodeficiency virus [HIV] infection status

Z21_ASYMP_HUMAN_IMMUNODEFICIENCY_VIRUS_HIV_INFECTION_STATUS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Z21
  • Cause of death: ICD-10 Z21

2 out of 7 registries used, show all original rules.

197

4. Check minimum number of events

None

197

5. Include endpoints

None

197

6. Filter based on genotype QC (FinnGen only)

176

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4
Parent code in ICD-10 Z2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1034 286 725
Only index persons 929 274 655
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.02 0.01 0.03
Median age at first event (years)
Whole population 37.15 31.93 39.40
Only index persons 36.71 31.33 38.96

-FinnGen-

Key figures

All Female Male
Number of individuals 176 32 144
Unadjusted period prevalence (%) 0.06 0.01 0.07
Median age at first event (years) 39.19 38.98 39.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint Z21_ASYMP_HUMAN_IMMUNODEFICIENCY_VIRUS_HIV_INFECTION_STATUS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
Z21_ASYMP_HUMAN_IMMUNODEFICIENCY_VIRUS_HIV_INFECTION_STATUS 2.926 [2.33, 3.68] < 0.001
Birth year 0.985 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 694 males with Z21_ASYMP_HUMAN_IMMUNODEFICIENCY_VIRUS_HIV_INFECTION_STATUS died.

Mortality risk

Mortality risk for people of age

years, who have Z21_ASYMP_HUMAN_IMMUNODEFICIENCY_VIRUS_HIV_INFECTION_STATUS.

N-year risk Females Males
1 No data 0.587%
5 No data 3.198%
10 No data 7.823%
15 No data 14.841%
20 No data 24.18%

Relationships between endpoints

Index endpoint: Z21_ASYMP_HUMAN_IMMUNODEFICIENCY_VIRUS_HIV_INFECTION_STATUS – Asymptomatic human immunodeficiency virus [HIV] infection status

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data