No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
15337 |
4. Check minimum number of eventsNone |
15337 |
5. Include endpointsNone |
15337 |
6. Filter based on genotype QC (FinnGen only) |
14734 |
Control definitions (FinnGen only)
Control exclude
ST19_INJURI_WRIST_HAND
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S6
Name in latin
Fractura carpi/manus
Similar endpoints
↥List of similar endpoints to
Fracture at wrist and hand level
based on the number of shared cases.
Similar with more cases:
- Injuries to the wrist and hand
- Injury, poisoning and certain other consequences of external causes
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 190674 | 63814 | 126117 |
| Only index persons | 181702 | 60613 | 121089 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.95 | 1.83 | 3.52 |
| Only index persons | 3.82 | 2.23 | 4.62 |
| Median age at first event (years) | |||
| Whole population | 34.20 | 43.33 | 29.57 |
| Only index persons | 34.33 | 43.67 | 29.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 14734 | 6598 | 8136 |
| Unadjusted period prevalence (%) | 3.42 | 2.59 | 4.09 |
| Median age at first event (years) | 47.23 | 49.15 | 45.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ST19_FRACT_WRIST_HAND_LEVEL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_WRIST_HAND_LEVEL | 1.306 [1.18, 1.45] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.096 |
During the follow-up period (1.1.1998 — 31.12.2019), 5941 out of 54197 females with ST19_FRACT_WRIST_HAND_LEVEL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_WRIST_HAND_LEVEL | 1.379 [1.25, 1.53] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 8114 out of 110901 males with ST19_FRACT_WRIST_HAND_LEVEL died.
Mortality risk
Mortality risk for people of age
years, who have ST19_FRACT_WRIST_HAND_LEVEL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.193% |
| 5 | 0.772% | 1.523% |
| 10 | 1.841% | 3.975% |
| 15 | 3.584% | 7.815% |
| 20 | 6.189% | 13.378% |
Relationships between endpoints
↥Index endpoint: ST19_FRACT_WRIST_HAND_LEVEL – Fracture at wrist and hand level
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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