No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
59 |
4. Check minimum number of eventsNone |
59 |
5. Include endpointsNone |
59 |
6. Filter based on genotype QC (FinnGen only) |
56 |
Control definitions (FinnGen only)
Control exclude
ST19_INJURI_UNSPE_PART_TRUNK_LIMB_BODY_REGION
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
T0[8-9]|T1[0-4]
Name in latin
Fractura columnae vertebralis, regione non specificata
Similar endpoints
↥List of similar endpoints to
Fracture of spine, level unspecified
based on the number of shared cases.
Similar with more cases:
- Injuries to unspecified part of trunk, limb or body region
- Injury, poisoning and certain other consequences of external causes
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 738 | 368 | 366 |
| Only index persons | 637 | 305 | 332 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 68.87 | 77.70 | 59.99 |
| Only index persons | 66.68 | 76.11 | 58.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 56 | 26 | 30 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 65.40 | 65.02 | 65.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint ST19_FRACT_SPINE_LEVEL_UNSPE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_SPINE_LEVEL_UNSPE | 1.876 [1.28, 2.74] | 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.263 |
During the follow-up period (1.1.1998 — 31.12.2019), 119 out of 271 females with ST19_FRACT_SPINE_LEVEL_UNSPE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_SPINE_LEVEL_UNSPE | 2.304 [1.4, 3.78] | 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 280 males with ST19_FRACT_SPINE_LEVEL_UNSPE died.
Mortality risk
Mortality risk for people of age
years, who have ST19_FRACT_SPINE_LEVEL_UNSPE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.23% | 0.388% |
| 5 | 1.078% | 2.665% |
| 10 | 2.559% | 6.877% |
| 15 | 5.06% | 12.868% |
| 20 | 8.965% | 21.156% |
Relationships between endpoints
↥Index endpoint: ST19_FRACT_SPINE_LEVEL_UNSPE – Fracture of spine, level unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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