No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
9003 |
4. Check minimum number of eventsNone |
9003 |
5. Include endpointsNone |
9003 |
6. Filter based on genotype QC (FinnGen only) |
8618 |
Control definitions (FinnGen only)
Control exclude
ST19_INJURI_HEAD
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S0
Name in latin
Fractura cranii
Similar endpoints
↥List of similar endpoints to
Fracture of skull and facial bones
based on the number of shared cases.
Similar with more cases:
- Injuries to the head
- Injury, poisoning and certain other consequences of external causes
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 110952 | 35934 | 74434 |
| Only index persons | 102229 | 33368 | 68861 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.73 | 1.03 | 2.08 |
| Only index persons | 2.17 | 1.23 | 2.63 |
| Median age at first event (years) | |||
| Whole population | 38.30 | 47.37 | 33.91 |
| Only index persons | 38.10 | 47.45 | 33.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8618 | 3616 | 5002 |
| Unadjusted period prevalence (%) | 2.05 | 1.42 | 2.51 |
| Median age at first event (years) | 47.94 | 49.05 | 47.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ST19_FRACT_SKULL_FACIAL_BONES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_SKULL_FACIAL_BONES | 1.602 [1.45, 1.77] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.186 |
During the follow-up period (1.1.1998 — 31.12.2019), 5051 out of 29358 females with ST19_FRACT_SKULL_FACIAL_BONES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_SKULL_FACIAL_BONES | 2.107 [1.9, 2.33] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 8818 out of 62752 males with ST19_FRACT_SKULL_FACIAL_BONES died.
Mortality risk
Mortality risk for people of age
years, who have ST19_FRACT_SKULL_FACIAL_BONES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.127% | 0.42% |
| 5 | 0.941% | 2.601% |
| 10 | 2.199% | 6.384% |
| 15 | 4.333% | 11.587% |
| 20 | 7.564% | 18.93% |
Relationships between endpoints
↥Index endpoint: ST19_FRACT_SKULL_FACIAL_BONES – Fracture of skull and facial bones
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data