No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1911 |
4. Check minimum number of eventsNone |
1911 |
5. Include endpointsNone |
1911 |
6. Filter based on genotype QC (FinnGen only) |
1859 |
Control definitions (FinnGen only)
Control exclude
ST19_INJURI_NECK
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S1
Name in latin
Fractura partis cervicalis columnae vertebralis
Similar endpoints
↥List of similar endpoints to
Fracture of neck
based on the number of shared cases.
Similar with more cases:
- Injuries to the neck
- Injury, poisoning and certain other consequences of external causes
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19285 | 6543 | 12652 |
| Only index persons | 17698 | 6097 | 11601 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.30 | 0.19 | 0.35 |
| Only index persons | 0.37 | 0.22 | 0.44 |
| Median age at first event (years) | |||
| Whole population | 62.27 | 70.35 | 58.06 |
| Only index persons | 61.50 | 69.47 | 57.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1859 | 650 | 1209 |
| Unadjusted period prevalence (%) | 0.48 | 0.26 | 0.61 |
| Median age at first event (years) | 62.65 | 62.02 | 62.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ST19_FRACT_NECK and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_NECK | 1.756 [1.51, 2.05] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.258 |
During the follow-up period (1.1.1998 — 31.12.2019), 1659 out of 5275 females with ST19_FRACT_NECK died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_NECK | 2.001 [1.75, 2.28] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 2750 out of 10214 males with ST19_FRACT_NECK died.
Mortality risk
Mortality risk for people of age
years, who have ST19_FRACT_NECK.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.113% | 0.453% |
| 5 | 0.918% | 2.48% |
| 10 | 2.629% | 5.806% |
| 15 | 5.089% | 11.172% |
| 20 | 8.813% | 18.838% |
Relationships between endpoints
↥Index endpoint: ST19_FRACT_NECK – Fracture of neck
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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