No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
8145 |
4. Check minimum number of eventsNone |
8145 |
5. Include endpointsNone |
8145 |
6. Filter based on genotype QC (FinnGen only) |
7867 |
Control definitions (FinnGen only)
Control exclude
ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S3
Name in latin
Fractura partis lumbalis columnae vertebralis
Similar endpoints
↥List of similar endpoints to
Fracture of lumbar spine and pelvis
based on the number of shared cases.
Similar with more cases:
- Injuries to the abdomen, lower back, lumbar spine and pelvis
- Injury, poisoning and certain other consequences of external causes
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 92287 | 54940 | 36862 |
| Only index persons | 80943 | 47896 | 33047 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.35 | 1.57 | 1.03 |
| Only index persons | 1.56 | 1.76 | 1.26 |
| Median age at first event (years) | |||
| Whole population | 71.40 | 77.87 | 61.74 |
| Only index persons | 70.24 | 77.08 | 60.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7867 | 4380 | 3487 |
| Unadjusted period prevalence (%) | 1.73 | 1.72 | 1.75 |
| Median age at first event (years) | 68.20 | 69.06 | 67.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ST19_FRACT_LUMBAR_SPINE_PELVIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_LUMBAR_SPINE_PELVIS | 1.708 [1.54, 1.89] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.113 |
During the follow-up period (1.1.1998 — 31.12.2019), 20751 out of 44874 females with ST19_FRACT_LUMBAR_SPINE_PELVIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_LUMBAR_SPINE_PELVIS | 2.21 [1.95, 2.5] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 10262 out of 30052 males with ST19_FRACT_LUMBAR_SPINE_PELVIS died.
Mortality risk
Mortality risk for people of age
years, who have ST19_FRACT_LUMBAR_SPINE_PELVIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.109% | 0.453% |
| 5 | 0.771% | 2.404% |
| 10 | 2.011% | 6.445% |
| 15 | 4.236% | 11.783% |
| 20 | 7.617% | 18.892% |
Relationships between endpoints
↥Index endpoint: ST19_FRACT_LUMBAR_SPINE_PELVIS – Fracture of lumbar spine and pelvis
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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