No definition available.
Fracture of lower leg, including ankle
EFO MESH Endpoint Browser PheWeb
ST19_FRACT_LOWER_LEG_INCLU_ANKLE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
25855 |
4. Check minimum number of eventsNone |
25855 |
5. Include endpointsNone |
25855 |
6. Filter based on genotype QC (FinnGen only) |
24999 |
Control definitions (FinnGen only)
Control exclude
ST19_INJURI_KNEE_LOWER_LEG
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S8
Name in latin
Fractura genus/cruris
Similar endpoints
↥List of similar endpoints to
Fracture of lower leg, including ankle
based on the number of shared cases.
Similar with more cases:
- Injuries to the knee and lower leg
- Injury, poisoning and certain other consequences of external causes
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 289332 | 144128 | 144076 |
| Only index persons | 267282 | 134001 | 133281 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.07 | 4.13 | 4.03 |
| Only index persons | 5.01 | 4.93 | 5.09 |
| Median age at first event (years) | |||
| Whole population | 48.02 | 55.36 | 40.64 |
| Only index persons | 47.58 | 55.08 | 40.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 24999 | 14536 | 10463 |
| Unadjusted period prevalence (%) | 5.52 | 5.71 | 5.25 |
| Median age at first event (years) | 52.52 | 54.15 | 50.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ST19_FRACT_LOWER_LEG_INCLU_ANKLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_LOWER_LEG_INCLU_ANKLE | 1.446 [1.33, 1.57] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.064 |
During the follow-up period (1.1.1998 — 31.12.2019), 22673 out of 122545 females with ST19_FRACT_LOWER_LEG_INCLU_ANKLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_LOWER_LEG_INCLU_ANKLE | 1.726 [1.58, 1.88] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 19285 out of 124322 males with ST19_FRACT_LOWER_LEG_INCLU_ANKLE died.
Mortality risk
Mortality risk for people of age
years, who have ST19_FRACT_LOWER_LEG_INCLU_ANKLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.13% | 0.276% |
| 5 | 0.689% | 1.676% |
| 10 | 1.712% | 4.381% |
| 15 | 3.443% | 8.759% |
| 20 | 6.329% | 14.803% |
Relationships between endpoints
↥Index endpoint: ST19_FRACT_LOWER_LEG_INCLU_ANKLE – Fracture of lower leg, including ankle
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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