No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
25531 |
4. Check minimum number of eventsNone |
25531 |
5. Include endpointsNone |
25531 |
6. Filter based on genotype QC (FinnGen only) |
24647 |
Control definitions (FinnGen only)
Control exclude
ST19_INJURI_ELBOW_FOREA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S5
Name in latin
Fractura antebrachii
Similar endpoints
↥List of similar endpoints to
Fracture of forearm
based on the number of shared cases.
Similar with more cases:
- Injuries to the elbow and forearm
- Injury, poisoning and certain other consequences of external causes
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 311001 | 188125 | 121988 |
| Only index persons | 286823 | 174141 | 112682 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.60 | 5.39 | 3.41 |
| Only index persons | 5.58 | 6.40 | 4.30 |
| Median age at first event (years) | |||
| Whole population | 44.86 | 59.43 | 22.30 |
| Only index persons | 45.13 | 59.19 | 23.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 24647 | 17362 | 7285 |
| Unadjusted period prevalence (%) | 5.88 | 6.82 | 3.66 |
| Median age at first event (years) | 56.11 | 58.33 | 50.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ST19_FRACT_FOREA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_FOREA | 1.14 [1.05, 1.23] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.02 |
During the follow-up period (1.1.1998 — 31.12.2019), 32191 out of 163840 females with ST19_FRACT_FOREA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_FOREA | 1.48 [1.34, 1.63] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 10652 out of 106984 males with ST19_FRACT_FOREA died.
Mortality risk
Mortality risk for people of age
years, who have ST19_FRACT_FOREA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.08% | 0.306% |
| 5 | 0.508% | 1.595% |
| 10 | 1.31% | 4.005% |
| 15 | 2.551% | 7.825% |
| 20 | 4.548% | 13.014% |
Relationships between endpoints
↥Index endpoint: ST19_FRACT_FOREA – Fracture of forearm
GWS hits: 24
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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