No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
10171 |
4. Check minimum number of eventsNone |
10171 |
5. Include endpointsNone |
10171 |
6. Filter based on genotype QC (FinnGen only) |
9782 |
Control definitions (FinnGen only)
Control exclude
ST19_INJURI_ANKLE_FOOT
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S90
Name in latin
Fractura tarsi/pedis
Similar endpoints
↥List of similar endpoints to
Fracture of foot, except ankle
based on the number of shared cases.
Similar with more cases:
- Injuries to the ankle and foot
- Injury, poisoning and certain other consequences of external causes
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 110942 | 49464 | 61038 |
| Only index persons | 104866 | 47072 | 57794 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.57 | 1.42 | 1.71 |
| Only index persons | 1.99 | 1.73 | 2.21 |
| Median age at first event (years) | |||
| Whole population | 37.26 | 42.72 | 32.83 |
| Only index persons | 37.57 | 42.97 | 33.17 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 9782 | 5757 | 4025 |
| Unadjusted period prevalence (%) | 2.16 | 2.26 | 2.02 |
| Median age at first event (years) | 48.13 | 47.81 | 48.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ST19_FRACT_FOOT_ANKLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_FOOT_ANKLE | 1.49 [1.34, 1.66] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.584 |
During the follow-up period (1.1.1998 — 31.12.2019), 4144 out of 40990 females with ST19_FRACT_FOOT_ANKLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_FRACT_FOOT_ANKLE | 1.49 [1.34, 1.65] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 4641 out of 52007 males with ST19_FRACT_FOOT_ANKLE died.
Mortality risk
Mortality risk for people of age
years, who have ST19_FRACT_FOOT_ANKLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.15% | 0.255% |
| 5 | 0.786% | 1.573% |
| 10 | 2.256% | 4.07% |
| 15 | 4.4% | 7.744% |
| 20 | 7.84% | 13.085% |
Relationships between endpoints
↥Index endpoint: ST19_FRACT_FOOT_ANKLE – Fracture of foot, except ankle
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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