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Fracture of femur

EFO MESH Endpoint Browser PheWeb

ST19_FRACT_FEMUR

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — S72
  • Hospital discharge: ICD-9 — 820
  • Hospital discharge: ICD-8 — 820
  • Cause of death: ICD-10 — S72
  • Cause of death: ICD-9 — 820
  • Cause of death: ICD-8 — 820

2 out of 7 registries used, show all original rules.

11160

4. Check minimum number of events

None

11160

5. Include endpoints

None

11160

6. Filter based on genotype QC (FinnGen only)

10714

Control definitions (FinnGen only)

Control exclude ST19_INJURI_HIP_THIGH

Extra metadata

Level in the ICD hierarchy 3
Special HIP_FRACTURE
First used in FinnGen datafreeze DF4
Parent code in ICD-10 S70-S79
Name in latin Fractura femoris

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 201890 126109 73573
Only index persons 141078 88226 52852
Unadjusted period prevalence (%)
Whole population 3.03 3.61 2.06
Only index persons 2.78 3.24 2.02
Median age at first event (years)
Whole population 77.16 80.61 71.28
Only index persons 76.37 81.00 68.63

-FinnGen-

Key figures

All Female Male
Number of individuals 10714 5337 5377
Unadjusted period prevalence (%) 2.40 2.10 2.70
Median age at first event (years) 74.19 74.92 73.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint ST19_FRACT_FEMUR and mortality.

Females

Parameter HR [95% CI] p-value
ST19_FRACT_FEMUR 2.03 [1.85, 2.23] < 0.001
Birth year 1.0 [0.99, 1.01] 0.952

During the follow-up period (1.1.1998 — 31.12.2019), 55287 out of 87325 females with ST19_FRACT_FEMUR died.

Males

Parameter HR [95% CI] p-value
ST19_FRACT_FEMUR 2.781 [2.44, 3.17] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 25200 out of 47711 males with ST19_FRACT_FEMUR died.

Mortality risk

Mortality risk for people of age

years, who have ST19_FRACT_FEMUR.

N-year risk Females Males
1 0.203% 0.39%
5 1.203% 2.593%
10 3.204% 6.321%
15 6.015% 11.715%
20 10.364% 19.733%

Relationships between endpoints

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Index endpoint: ST19_FRACT_FEMUR – Fracture of femur

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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