No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
815 |
4. Check minimum number of eventsNone |
815 |
5. Include endpointsNone |
815 |
6. Filter based on genotype QC (FinnGen only) |
786 |
Control definitions (FinnGen only)
Control exclude
G6_POLYNEU
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Small fibre neuropathy
based on the number of shared cases.
Similar with more cases:
- Polyneuropathies and other disorders of the peripheral nervous system
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4420 | 1835 | 2568 |
| Only index persons | 4164 | 1744 | 2420 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.05 | 0.07 |
| Only index persons | 0.08 | 0.06 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 63.93 | 64.22 | 63.77 |
| Only index persons | 63.81 | 64.02 | 63.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 786 | 343 | 443 |
| Unadjusted period prevalence (%) | 0.18 | 0.13 | 0.22 |
| Median age at first event (years) | 64.75 | 63.18 | 65.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint SFN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SFN | 2.127 [1.75, 2.58] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.556 |
During the follow-up period (1.1.1998 — 31.12.2019), 319 out of 1445 females with SFN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SFN | 1.787 [1.5, 2.13] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.059 |
During the follow-up period (1.1.1998 — 31.12.2019), 535 out of 2049 males with SFN died.
Mortality risk
Mortality risk for people of age
years, who have SFN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.152% | 0.371% |
| 5 | 1.346% | 2.018% |
| 10 | 3.672% | 4.985% |
| 15 | 6.693% | 9.373% |
| 20 | 10.957% | 15.86% |
Relationships between endpoints
↥Index endpoint: SFN – Small fibre neuropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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