No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1093 |
4. Check minimum number of eventsNone |
1093 |
5. Include endpointsNone |
1093 |
6. Filter based on genotype QC (FinnGen only) |
1054 |
Control definitions (FinnGen only)
Control exclude
COX_ARTHROSIS
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M16
Name in latin
Alia coxarthrosis secundaria
Similar endpoints
↥List of similar endpoints to
Other secondary coxarthrosis
based on the number of shared cases.
Similar with more cases:
- Coxarthrosis
- Coxarthrosis [arthrosis of hip](FG)
- Arthrosis
- Finngen Rheumatological endpoints
- Artrosis, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9231 | 4924 | 4215 |
| Only index persons | 7599 | 4223 | 3376 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.14 | 0.12 |
| Only index persons | 0.14 | 0.16 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 57.39 | 58.73 | 55.66 |
| Only index persons | 54.94 | 56.62 | 52.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1054 | 591 | 463 |
| Unadjusted period prevalence (%) | 0.23 | 0.23 | 0.23 |
| Median age at first event (years) | 55.31 | 54.66 | 56.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint SCND_OTH_COXARTHROSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SCND_OTH_COXARTHROSIS | 1.241 [1.1, 1.4] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.091 |
During the follow-up period (1.1.1998 — 31.12.2019), 576 out of 2900 females with SCND_OTH_COXARTHROSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SCND_OTH_COXARTHROSIS | 1.309 [1.14, 1.5] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 511 out of 2439 males with SCND_OTH_COXARTHROSIS died.
Mortality risk
Mortality risk for people of age
years, who have SCND_OTH_COXARTHROSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.113% | 0.202% |
| 5 | 0.711% | 1.345% |
| 10 | 1.79% | 3.359% |
| 15 | 3.356% | 6.236% |
| 20 | 5.844% | 10.313% |
Relationships between endpoints
↥Index endpoint: SCND_OTH_COXARTHROSIS – Other secondary coxarthrosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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