No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
80070 |
4. Check minimum number of events
Min. number of events
3
|
80070 |
5. Include endpointsNone |
80070 |
6. Filter based on genotype QC (FinnGen only) |
77222 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Use of hypnotics and sedatives
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 791068 | 467501 | 316347 |
| Only index persons | 649689 | 398173 | 251516 |
| Unadjusted period prevalence (%) | |||
| Whole population | 11.52 | 13.39 | 8.84 |
| Only index persons | 12.69 | 14.64 | 9.60 |
| Median age at first event (years) | |||
| Whole population | 57.02 | 58.33 | 54.85 |
| Only index persons | 54.22 | 55.71 | 51.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 77222 | 45553 | 31669 |
| Unadjusted period prevalence (%) | 17.08 | 17.89 | 15.90 |
| Median age at first event (years) | 52.25 | 50.10 | 55.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint RX_N05C and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RX_N05C | 1.11 [1.04, 1.18] | 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.3 |
During the follow-up period (1.1.1998 — 31.12.2019), 70922 out of 292693 females with RX_N05C died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RX_N05C | 1.566 [1.46, 1.68] | < 0.001 |
| Birth year | 0.987 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 67683 out of 212291 males with RX_N05C died.
Mortality risk
Mortality risk for people of age
years, who have RX_N05C.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | 0.214% |
| 5 | 0.599% | 1.512% |
| 10 | 1.465% | 4.079% |
| 15 | 2.854% | 7.63% |
| 20 | 5.057% | 12.536% |
Relationships between endpoints
↥Index endpoint: RX_N05C – Use of hypnotics and sedatives
GWS hits: 33
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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