No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
25585 |
4. Check minimum number of events
Min. number of events
3
|
25585 |
5. Include endpointsNone |
25585 |
6. Filter based on genotype QC (FinnGen only) |
24774 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF5
Second line medication for Crohn's disease
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 143874 | 84541 | 58823 |
| Only index persons | 136668 | 80893 | 55775 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.10 | 2.42 | 1.64 |
| Only index persons | 2.63 | 2.97 | 2.13 |
| Median age at first event (years) | |||
| Whole population | 53.34 | 53.97 | 52.43 |
| Only index persons | 53.04 | 53.70 | 52.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 24774 | 15311 | 9463 |
| Unadjusted period prevalence (%) | 5.53 | 6.01 | 4.75 |
| Median age at first event (years) | 52.65 | 51.53 | 54.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint RX_CROHN_2NDLINE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RX_CROHN_2NDLINE | 1.489 [1.37, 1.62] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.426 |
During the follow-up period (1.1.1998 — 31.12.2019), 9945 out of 74466 females with RX_CROHN_2NDLINE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RX_CROHN_2NDLINE | 1.482 [1.35, 1.63] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 7804 out of 50876 males with RX_CROHN_2NDLINE died.
Mortality risk
Mortality risk for people of age
years, who have RX_CROHN_2NDLINE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.109% | 0.213% |
| 5 | 0.853% | 1.45% |
| 10 | 2.094% | 3.974% |
| 15 | 4.265% | 7.84% |
| 20 | 7.491% | 13.469% |
Relationships between endpoints
↥Index endpoint: RX_CROHN_2NDLINE – Second line medication for Crohn's disease
GWS hits: 35
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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