No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
96808 |
4. Check minimum number of events
Min. number of events
3
|
96808 |
5. Include endpointsNone |
96808 |
6. Filter based on genotype QC (FinnGen only) |
93616 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 696216 | 397475 | 293994 |
Only index persons | 620665 | 362085 | 258580 |
Unadjusted period prevalence (%) | |||
Whole population | 10.00 | 11.38 | 8.21 |
Only index persons | 11.88 | 13.31 | 9.87 |
Median age at first event (years) | |||
Whole population | 55.02 | 54.12 | 56.08 |
Only index persons | 53.29 | 52.63 | 54.22 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 93616 | 54893 | 38723 |
Unadjusted period prevalence (%) | 20.69 | 21.56 | 19.45 |
Median age at first event (years) | 51.75 | 48.00 | 57.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint RX_CROHN_1STLINE and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
RX_CROHN_1STLINE | 1.511 [1.41, 1.62] | < 0.001 |
Birth year | 0.991 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 63408 out of 305582 females with RX_CROHN_1STLINE died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
RX_CROHN_1STLINE | 1.631 [1.51, 1.76] | < 0.001 |
Birth year | 0.985 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 62895 out of 230905 males with RX_CROHN_1STLINE died.
Mortality risk
Mortality risk for people of age
years, who have RX_CROHN_1STLINE.N-year risk | Females | Males |
---|---|---|
1 | 0.125% | 0.264% |
5 | 0.669% | 1.507% |
10 | 1.649% | 3.724% |
15 | 3.146% | 7.037% |
20 | 5.486% | 11.911% |
Relationships between endpoints
↥Index endpoint: RX_CROHN_1STLINE – First line medication for Crohn's disease
GWS hits: 40