First line medication for Crohn's disease

RX_CROHN_1STLINE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Medicine purchases: ATC A07EC|H02AB

1 out of 7 registries used, show all original rules.

96808

4. Check minimum number of events

Min. number of events 3
96808

5. Include endpoints

None

96808

6. Filter based on genotype QC (FinnGen only)

93616

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 696216 397475 293994
Only index persons 620665 362085 258580
Unadjusted period prevalence (%)
Whole population 10.00 11.38 8.21
Only index persons 11.88 13.31 9.87
Median age at first event (years)
Whole population 55.02 54.12 56.08
Only index persons 53.29 52.63 54.22

-FinnGen-

Key figures

All Female Male
Number of individuals 93616 54893 38723
Unadjusted period prevalence (%) 20.69 21.56 19.45
Median age at first event (years) 51.75 48.00 57.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint RX_CROHN_1STLINE and mortality.

Females

Parameter HR [95% CI] p-value
RX_CROHN_1STLINE 1.511 [1.41, 1.62] < 0.001
Birth year 0.991 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 63408 out of 305582 females with RX_CROHN_1STLINE died.

Males

Parameter HR [95% CI] p-value
RX_CROHN_1STLINE 1.631 [1.51, 1.76] < 0.001
Birth year 0.985 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 62895 out of 230905 males with RX_CROHN_1STLINE died.

Mortality risk

Mortality risk for people of age

years, who have RX_CROHN_1STLINE.

N-year risk Females Males
1 0.125% 0.264%
5 0.669% 1.507%
10 1.649% 3.724%
15 3.146% 7.037%
20 5.486% 11.911%

Relationships between endpoints

Index endpoint: RX_CROHN_1STLINE – First line medication for Crohn's disease

GWS hits: 40

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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