No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
515 |
4. Check minimum number of eventsNone |
515 |
5. Include endpointsNone |
515 |
6. Filter based on genotype QC (FinnGen only) |
493 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Anorexia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6577 | 4584 | 1950 |
| Only index persons | 5178 | 3786 | 1392 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.05 |
| Only index persons | 0.12 | 0.14 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 21.18 | 18.99 | 25.35 |
| Only index persons | 19.50 | 18.42 | 22.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 493 | 385 | 108 |
| Unadjusted period prevalence (%) | 0.13 | 0.15 | 0.05 |
| Median age at first event (years) | 28.14 | 19.88 | 57.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint R18_ANOREXIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| R18_ANOREXIA | 2.716 [2.11, 3.49] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.099 |
During the follow-up period (1.1.1998 — 31.12.2019), 508 out of 2219 females with R18_ANOREXIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| R18_ANOREXIA | 3.85 [2.44, 6.09] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 1088 males with R18_ANOREXIA died.
Mortality risk
Mortality risk for people of age
years, who have R18_ANOREXIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.251% | 0.774% |
| 5 | 1.631% | 4.47% |
| 10 | 3.628% | 10.666% |
| 15 | 6.819% | 19.76% |
| 20 | 11.606% | 31.491% |
Relationships between endpoints
↥Index endpoint: R18_ANOREXIA – Anorexia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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