cryptorchidism: The failure of one or both testes of a male fetus to descend from the abdomen into the scrotum during the late part of pregnancy. If not surgically corrected in early childhood, males may be at increased risk for testicular cancer later in life.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
367 |
4. Check minimum number of eventsNone |
367 |
5. Include endpointsNone |
367 |
6. Filter based on genotype QC (FinnGen only) |
337 |
Control definitions (FinnGen only)
Control exclude
Q17_CONGEN_MALFO_GENITAL_ORGANS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q5
Name in latin
Retentio testis
Similar endpoints
↥List of similar endpoints to
Undescended testicle
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of genital organs
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16828 | 36 | 16778 |
| Only index persons | 11998 | 32 | 11966 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.47 | 0.00 | 0.47 |
| Only index persons | 0.46 | 0.00 | 0.46 |
| Median age at first event (years) | |||
| Whole population | 1.98 | 16.40 | 1.90 |
| Only index persons | 3.50 | 19.77 | 3.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 337 | - | 334 |
| Unadjusted period prevalence (%) | 0.17 | - | 0.17 |
| Median age at first event (years) | 7.49 | - | 7.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint Q17_UNDES_TESTICLE and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_UNDES_TESTICLE | 1.601 [1.29, 1.99] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 188 out of 14821 males with Q17_UNDES_TESTICLE died.
Mortality risk
Mortality risk for people of age
years, who have Q17_UNDES_TESTICLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.263% |
| 5 | No data | 1.753% |
| 10 | No data | 4.631% |
| 15 | No data | 8.523% |
| 20 | No data | 14.385% |
Relationships between endpoints
↥Index endpoint: Q17_UNDES_TESTICLE – Undescended testicle
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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