No definition available.
Renal agenesis and other reduction defects of kidney
Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
158 |
4. Check minimum number of eventsNone |
158 |
5. Include endpointsNone |
158 |
6. Filter based on genotype QC (FinnGen only) |
148 |
Control definitions (FinnGen only)
Control exclude
Q17_CONGEN_MALFO_URINARY_SYSTEM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q6[0-4]
Name in latin
Agenesis/aplasia/hypoplasia/atrophia renis/renum
Similar endpoints
↥List of similar endpoints to
Renal agenesis and other reduction defects of kidney
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the urinary system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1672 | 714 | 949 |
| Only index persons | 1260 | 565 | 695 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 14.59 | 17.97 | 11.61 |
| Only index persons | 24.56 | 26.79 | 22.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 148 | 60 | 88 |
| Unadjusted period prevalence (%) | 0.04 | 0.02 | 0.04 |
| Median age at first event (years) | 43.35 | 36.87 | 47.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY | 3.495 [2.57, 4.75] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.485 |
During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 613 females with Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY | 2.759 [2.09, 3.65] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 799 males with Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY died.
Mortality risk
Mortality risk for people of age
years, who have Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.299% | 0.571% |
| 5 | 2.066% | 2.868% |
| 10 | 5.114% | 7.129% |
| 15 | 10.314% | 13.517% |
| 20 | 17.723% | 22.645% |
Relationships between endpoints
↥Index endpoint: Q17_RENAL_AGENE_OTHER_REDUCT_DEFECTS_KIDNEY – Renal agenesis and other reduction defects of kidney
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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