No definition available.
Other congenital malformations of nervous system
Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
330 |
4. Check minimum number of eventsNone |
330 |
5. Include endpointsNone |
330 |
6. Filter based on genotype QC (FinnGen only) |
320 |
Control definitions (FinnGen only)
Control exclude
Q17_CONGEN_MALFO_NERVOUS_SYSTEM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q0
Name in latin
Aliae malformationes congenitae systematis nervosi
Similar endpoints
↥List of similar endpoints to
Other congenital malformations of nervous system
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the nervous system
- Congenital malformations, deformations and chromosomal abnormalities
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3361 | 2035 | 1322 |
| Only index persons | 2889 | 1839 | 1050 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.04 |
| Only index persons | 0.06 | 0.07 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 19.42 | 24.31 | 11.87 |
| Only index persons | 23.03 | 27.09 | 15.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 320 | 259 | 61 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.03 |
| Median age at first event (years) | 32.02 | 32.16 | 31.43 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM | 1.466 [1.11, 1.94] | 0.008 |
| Birth year | 1.002 [0.99, 1.01] | 0.727 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 1703 females with Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM | 2.062 [1.43, 2.98] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 1152 males with Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | 0.435% |
| 5 | 1.029% | 2.466% |
| 10 | 2.689% | 5.886% |
| 15 | 4.951% | 11.231% |
| 20 | 8.946% | 18.364% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_CONGEN_MALFO_NERVOUS_SYSTEM – Other congenital malformations of nervous system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data