No definition available.
Other congenital malformations of circulatory system
EFO MESH Endpoint Browser PheWeb
Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
817 |
4. Check minimum number of eventsNone |
817 |
5. Include endpointsNone |
817 |
6. Filter based on genotype QC (FinnGen only) |
789 |
Control definitions (FinnGen only)
Control exclude
Q17_CONGEN_MALFO_CIRCULATO_SYSTEM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q2
Name in latin
Aliae malformationes congenitae systematis circulatorii
Similar endpoints
↥List of similar endpoints to
Other congenital malformations of circulatory system
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the circulatory system
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5679 | 2954 | 2695 |
| Only index persons | 5251 | 2773 | 2478 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.10 | 0.10 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 50.81 | 51.53 | 50.08 |
| Only index persons | 51.08 | 51.74 | 50.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 789 | 449 | 340 |
| Unadjusted period prevalence (%) | 0.17 | 0.18 | 0.17 |
| Median age at first event (years) | 54.19 | 52.07 | 57.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM | 1.412 [1.2, 1.67] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.218 |
During the follow-up period (1.1.1998 — 31.12.2019), 247 out of 2415 females with Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM | 1.509 [1.28, 1.78] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.02 |
During the follow-up period (1.1.1998 — 31.12.2019), 309 out of 2209 males with Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.111% | 0.301% |
| 5 | 0.689% | 1.751% |
| 10 | 1.803% | 4.426% |
| 15 | 3.836% | 8.529% |
| 20 | 6.932% | 14.452% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM – Other congenital malformations of circulatory system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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