Left ventricular outflow tract obstruction, narrow definition

Q17_LVOTO_NARROW

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q23, Q24.4, Q25.1, Q25.20, Q25.3, Q25.40
  • Hospital discharge: ICD-9 7463A|7464A|7463D|7465A|7466A|7467A|7468X|7463X|7471A|7472B|7471B
  • Hospital discharge: excluded ICD-10 Q90|Q91|Q92|Q93|Q96|Q8780|Q8781|Q8782|Q8783|Q8784|Q8786|Q8788|Q85|Q796|Q874|Q875
  • Hospital discharge: excluded ICD-9 758|7595|75683
  • Cause of death: ICD-10 Q23, Q24.4, Q25.1, Q25.20, Q25.3, Q25.40
  • Cause of death: ICD-9 7463A|7464A|7463D|7465A|7466A|7467A|7468X|7463X|7471A|7472B|7471B
  • Cause of death: excluded ICD-10 Q90|Q91|Q92|Q93|Q96|Q8780|Q8781|Q8782|Q8783|Q8784|Q8786|Q8788|Q85|Q796|Q874|Q875
  • Cause of death: excluded ICD-9 758|7595|75683

2 out of 7 registries used, show all original rules.

1631

4. Check minimum number of events

None

1631

5. Include endpoints

None

1631

6. Filter based on genotype QC (FinnGen only)

1561

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14391 5274 9068
Only index persons 11312 4077 7235
Unadjusted period prevalence (%)
Whole population 0.22 0.15 0.25
Only index persons 0.23 0.15 0.28
Median age at first event (years)
Whole population 18.56 15.60 20.08
Only index persons 29.81 26.79 31.51

-FinnGen-

Key figures

All Female Male
Number of individuals 1561 554 1007
Unadjusted period prevalence (%) 0.40 0.22 0.51
Median age at first event (years) 47.62 42.34 50.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint Q17_LVOTO_NARROW and mortality.

Females

Parameter HR [95% CI] p-value
Q17_LVOTO_NARROW 2.247 [1.81, 2.8] < 0.001
Birth year 0.991 [0.98, 1.0] 0.053

During the follow-up period (1.1.1998 — 31.12.2019), 263 out of 3839 females with Q17_LVOTO_NARROW died.

Males

Parameter HR [95% CI] p-value
Q17_LVOTO_NARROW 1.537 [1.3, 1.81] < 0.001
Birth year 0.99 [0.98, 1.0] 0.082

During the follow-up period (1.1.1998 — 31.12.2019), 418 out of 6581 males with Q17_LVOTO_NARROW died.

Mortality risk

Mortality risk for people of age

years, who have Q17_LVOTO_NARROW.

N-year risk Females Males
1 0.212% 0.276%
5 1.202% 1.713%
10 2.968% 4.62%
15 5.465% 8.948%
20 9.766% 15.278%

Relationships between endpoints

Index endpoint: Q17_LVOTO_NARROW – Left ventricular outflow tract obstruction, narrow definition

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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