Cystic Kidney Disease: A congenital or acquired kidney disorder characterized by the presence of renal cysts.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1072 |
4. Check minimum number of eventsNone |
1072 |
5. Include endpointsNone |
1072 |
6. Filter based on genotype QC (FinnGen only) |
1027 |
Control definitions (FinnGen only)
Control exclude
Q17_CONGEN_MALFO_URINARY_SYSTEM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q6[0-4]
Name in latin
Morbus cysticus renalis
Similar endpoints
↥List of similar endpoints to
Cystic kidney disease
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the urinary system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Congenital malformations, deformations and chromosomal abnormalities
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7148 | 3396 | 3699 |
| Only index persons | 5893 | 2890 | 3003 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.10 | 0.10 |
| Only index persons | 0.11 | 0.11 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 47.37 | 45.55 | 48.78 |
| Only index persons | 47.88 | 46.08 | 49.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1027 | 525 | 502 |
| Unadjusted period prevalence (%) | 0.23 | 0.21 | 0.25 |
| Median age at first event (years) | 50.08 | 48.64 | 51.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CYSTIC_KIDNEY_DISEA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CYSTIC_KIDNEY_DISEA | 1.986 [1.72, 2.29] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.105 |
During the follow-up period (1.1.1998 — 31.12.2019), 491 out of 2850 females with Q17_CYSTIC_KIDNEY_DISEA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CYSTIC_KIDNEY_DISEA | 2.041 [1.76, 2.36] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 734 out of 3060 males with Q17_CYSTIC_KIDNEY_DISEA died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CYSTIC_KIDNEY_DISEA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.203% | 0.313% |
| 5 | 1.092% | 1.766% |
| 10 | 2.836% | 4.806% |
| 15 | 5.4% | 9.406% |
| 20 | 9.38% | 15.342% |
Relationships between endpoints
↥Index endpoint: Q17_CYSTIC_KIDNEY_DISEA – Cystic kidney disease
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data