No definition available.
Congenital obstructive defects of renal pelvis and congenital malformations of ureter
EFO MESH Endpoint Browser PheWeb
Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
661 |
4. Check minimum number of eventsNone |
661 |
5. Include endpointsNone |
661 |
6. Filter based on genotype QC (FinnGen only) |
623 |
Control definitions (FinnGen only)
Control exclude
Q17_CONGEN_MALFO_URINARY_SYSTEM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q6[0-4]
Name in latin
Defectus obstructivi congeniti pelvis renalis
Similar endpoints
↥List of similar endpoints to
Congenital obstructive defects of renal pelvis and congenital malformations of ureter
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the urinary system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10797 | 5507 | 5270 |
| Only index persons | 8505 | 4638 | 3867 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.16 | 0.15 |
| Only index persons | 0.16 | 0.17 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 2.92 | 4.58 | 1.05 |
| Only index persons | 4.71 | 6.19 | 2.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 623 | 412 | 211 |
| Unadjusted period prevalence (%) | 0.14 | 0.16 | 0.11 |
| Median age at first event (years) | 21.68 | 23.67 | 17.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER | 1.465 [1.2, 1.79] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.145 |
During the follow-up period (1.1.1998 — 31.12.2019), 184 out of 4672 females with Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER | 1.668 [1.31, 2.13] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 136 out of 4660 males with Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.297% |
| 5 | 0.765% | 1.81% |
| 10 | 1.936% | 4.479% |
| 15 | 3.673% | 8.582% |
| 20 | 6.517% | 15.033% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_OBSTRUCTIVE_DEFECTS_RENAL_PELVIS_CONGEN_MALFO_URETER – Congenital obstructive defects of renal pelvis and congenital malformations of ureter
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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