No definition available.
Congenital malformations of trachea and bronchus
Q17_CONGEN_MALFO_TRACHEA_BRONCHUS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
301 |
4. Check minimum number of eventsNone |
301 |
5. Include endpointsNone |
301 |
6. Filter based on genotype QC (FinnGen only) |
292 |
Control definitions (FinnGen only)
Control exclude
Q17_CONGEN_MALFO_RESPI_SYSTEM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q3[0-4]
Name in latin
Malformationes congenitae tracheae et bronchorum
Similar endpoints
↥List of similar endpoints to
Congenital malformations of trachea and bronchus
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the respiratory system
- Congenital malformations, deformations and chromosomal abnormalities
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2594 | 1354 | 1230 |
| Only index persons | 2115 | 1173 | 942 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 44.83 | 59.59 | 28.36 |
| Only index persons | 55.76 | 60.59 | 49.76 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 292 | 181 | 111 |
| Unadjusted period prevalence (%) | 0.07 | 0.07 | 0.06 |
| Median age at first event (years) | 60.23 | 59.65 | 61.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_TRACHEA_BRONCHUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_TRACHEA_BRONCHUS | 1.555 [1.29, 1.87] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.321 |
During the follow-up period (1.1.1998 — 31.12.2019), 247 out of 1161 females with Q17_CONGEN_MALFO_TRACHEA_BRONCHUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_TRACHEA_BRONCHUS | 1.684 [1.38, 2.06] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 213 out of 1065 males with Q17_CONGEN_MALFO_TRACHEA_BRONCHUS died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_TRACHEA_BRONCHUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.15% | 0.306% |
| 5 | 1.047% | 1.854% |
| 10 | 2.408% | 4.856% |
| 15 | 4.395% | 9.008% |
| 20 | 7.683% | 14.552% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_TRACHEA_BRONCHUS – Congenital malformations of trachea and bronchus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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