No definition available.
Congenital malformations of pulmonary and tricuspid valves
Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
261 |
4. Check minimum number of eventsNone |
261 |
5. Include endpointsNone |
261 |
6. Filter based on genotype QC (FinnGen only) |
242 |
Control definitions (FinnGen only)
Control exclude
Q17_CONGEN_MALFO_CIRCULATO_SYSTEM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q2
Name in latin
Malformationes congenitae valvae (trunci) pulmonalis et valvae tricuspidalis
Similar endpoints
↥List of similar endpoints to
Congenital malformations of pulmonary and tricuspid valves
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations of the circulatory system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3353 | 1847 | 1493 |
| Only index persons | 2303 | 1282 | 1021 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 1.11 | 1.00 | 0.99 |
| Only index persons | 6.33 | 6.78 | 5.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 242 | 141 | 101 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.05 |
| Median age at first event (years) | 10.37 | 14.22 | 5.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES | 3.441 [2.43, 4.87] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.268 |
During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 1682 females with Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES | 4.147 [3.13, 5.5] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 1349 males with Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.287% | 0.541% |
| 5 | 2.239% | 5.113% |
| 10 | 5.248% | 12.434% |
| 15 | 9.974% | 22.743% |
| 20 | 16.615% | 36.333% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_PULMONARY_TRICU_VALVES – Congenital malformations of pulmonary and tricuspid valves
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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