No definition available.
Congenital malformations of gallbladder, bile ducts and liver
Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
279 |
4. Check minimum number of eventsNone |
279 |
5. Include endpointsNone |
279 |
6. Filter based on genotype QC (FinnGen only) |
269 |
Control definitions (FinnGen only)
Control exclude
Q17_OTHER_CONGEN_MALFO_DIGES_SYSTEM1
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q3[8-9]|Q4[0-5]
Name in latin
Malformationes congenitae vesicae biliaris, ductuum biliarium et hepatis
Similar endpoints
↥List of similar endpoints to
Congenital malformations of gallbladder, bile ducts and liver
based on the number of shared cases.
Similar with more cases:
- Other congenital malformations of the digestive system
- Congenital malformations, deformations and chromosomal abnormalities
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1971 | 1312 | 646 |
| Only index persons | 1660 | 1143 | 517 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 55.99 | 55.62 | 56.39 |
| Only index persons | 56.48 | 55.83 | 57.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 269 | 190 | 79 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.04 |
| Median age at first event (years) | 51.76 | 49.63 | 56.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER | 1.328 [1.1, 1.6] | 0.003 |
| Birth year | 1.002 [0.99, 1.01] | 0.663 |
During the follow-up period (1.1.1998 — 31.12.2019), 200 out of 1032 females with Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER | 1.368 [1.01, 1.86] | 0.044 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 130 out of 506 males with Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.181% | 0.232% |
| 5 | 1.032% | 1.42% |
| 10 | 2.439% | 3.794% |
| 15 | 4.731% | 7.375% |
| 20 | 8.411% | 12.237% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_GALLB_BILE_DUCTS_LIVER – Congenital malformations of gallbladder, bile ducts and liver
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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