No definition available.
Congenital malformations of cardiac chambers and connections
Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
200 |
4. Check minimum number of eventsNone |
200 |
5. Include endpointsNone |
200 |
6. Filter based on genotype QC (FinnGen only) |
187 |
Control definitions (FinnGen only)
Control exclude
Q17_CONGEN_MALFO_CIRCULATO_SYSTEM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q2
Name in latin
Malformationes congenitae loculorum et connectionum cordis
Similar endpoints
↥List of similar endpoints to
Congenital malformations of cardiac chambers and connections
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations of the circulatory system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Congenital malformations, deformations and chromosomal abnormalities
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1715 | 717 | 996 |
| Only index persons | 1148 | 491 | 657 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 2.36 | 3.16 | 1.67 |
| Only index persons | 8.28 | 9.82 | 7.14 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 187 | 75 | 112 |
| Unadjusted period prevalence (%) | 0.05 | 0.03 | 0.06 |
| Median age at first event (years) | 7.18 | 6.86 | 7.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO | 9.355 [4.38, 19.97] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.586 |
During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 576 females with Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO | 7.222 [4.72, 11.04] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 760 males with Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.913% | 1.304% |
| 5 | 6.522% | 6.938% |
| 10 | 15.52% | 17.531% |
| 15 | 25.751% | 31.095% |
| 20 | 40.699% | 46.393% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_CARDIAC_CHAMB_CONNECTIO – Congenital malformations of cardiac chambers and connections
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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