No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
633 |
4. Check minimum number of eventsNone |
633 |
5. Include endpointsNone |
633 |
6. Filter based on genotype QC (FinnGen only) |
601 |
Control definitions (FinnGen only)
Control exclude
Q17_CONGEN_MALFO_DEFORMAT_MUSCULOS_SYSTEM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q6[5-9]|Q7
Name in latin
Deformitates congenitae coxae
Similar endpoints
↥List of similar endpoints to
Congenital deformities of hip
based on the number of shared cases.
Similar with more cases:
- Congenital malformations and deformations of the musculoskeletal system
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17520 | 12354 | 5155 |
| Only index persons | 11084 | 7907 | 3177 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.35 | 0.14 |
| Only index persons | 0.24 | 0.29 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 0.08 | 0.05 | 0.06 |
| Only index persons | 0.13 | 0.10 | 0.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 601 | 498 | 103 |
| Unadjusted period prevalence (%) | 0.17 | 0.20 | 0.05 |
| Median age at first event (years) | 27.06 | 28.14 | 21.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_DEFORMITI_HIP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_DEFORMITI_HIP | 1.38 [1.15, 1.65] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.083 |
During the follow-up period (1.1.1998 — 31.12.2019), 242 out of 11663 females with Q17_CONGEN_DEFORMITI_HIP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_DEFORMITI_HIP | 1.696 [1.33, 2.16] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.15 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 4808 males with Q17_CONGEN_DEFORMITI_HIP died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_DEFORMITI_HIP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.113% | 0.388% |
| 5 | 0.763% | 2.236% |
| 10 | 1.75% | 5.465% |
| 15 | 3.518% | 10.243% |
| 20 | 6.237% | 17.495% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_DEFORMITI_HIP – Congenital deformities of hip
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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