No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
870 |
4. Check minimum number of eventsNone |
870 |
5. Include endpointsNone |
870 |
6. Filter based on genotype QC (FinnGen only) |
835 |
Control definitions (FinnGen only)
Control exclude
Q17_CONGEN_MALFO_DEFORMAT_MUSCULOS_SYSTEM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q6[5-9]|Q7
Name in latin
Deformitates congenitae pedum
Similar endpoints
↥List of similar endpoints to
Congenital deformities of feet
based on the number of shared cases.
Similar with more cases:
- Congenital malformations and deformations of the musculoskeletal system
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12688 | 5897 | 6770 |
| Only index persons | 10876 | 5130 | 5746 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.17 | 0.19 |
| Only index persons | 0.20 | 0.19 | 0.22 |
| Median age at first event (years) | |||
| Whole population | 10.23 | 12.31 | 8.35 |
| Only index persons | 12.68 | 14.50 | 11.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 835 | 520 | 315 |
| Unadjusted period prevalence (%) | 0.19 | 0.20 | 0.16 |
| Median age at first event (years) | 35.65 | 38.45 | 31.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_DEFORMITI_FEET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_DEFORMITI_FEET | 1.245 [1.01, 1.53] | 0.039 |
| Birth year | 0.997 [0.99, 1.01] | 0.516 |
During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 5121 females with Q17_CONGEN_DEFORMITI_FEET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_DEFORMITI_FEET | 1.2 [0.98, 1.48] | 0.085 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 158 out of 5999 males with Q17_CONGEN_DEFORMITI_FEET died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_DEFORMITI_FEET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.132% | 0.187% |
| 5 | 0.679% | 1.352% |
| 10 | 1.731% | 3.274% |
| 15 | 3.539% | 6.665% |
| 20 | 6.656% | 10.99% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_DEFORMITI_FEET – Congenital deformities of feet
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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